Developed the first cobalt-60 radiation therapy unit, paving the way for the high-voltage therapy in worldwide use today.
Grimmett L.G. A 1000-Curie Cobalt-60 Irradiator. Texas Reports on Biology and Medicine, 1950; 8 480-490.
Grimmett L.G., Kerman H.D., Brucer M., Fletcher G.H., and Richardson J.E. Design and Construction of a Multicurie Cobalt Teletherapy Unit. Radiology, Vol. 59, No. 1, Pages 19-29, July, 1952.
Demonstrated in clinical studies that “lumpectomy” followed by radiation therapy for breast cancer can be as effective as radical surgical mastectomy, now standard practice worldwide.
Fletcher GH, Montague ED, Nelson AJ. Combination of conservative surgery and irradiation for cancer of the breast. Am J Roentgenol, 126(2):216-22, 1976.
Fisher B, Montague ED, Redmond C, Barton B, Borland D, Fisher ER, Deutsch M, Schwarz G, Margolese R, Donegan W, Volk H, Konvolinka C, Gardner B, Cohn I Jr, Lesnick G, Cruz AB, Lawrence W, Nealon T, Butcher H, Lawton R. Comparison of radical mastectomy with alternative treatments for primary breast cancer: a first report of results from a prospective randomized clinical trial. Cancer, 39(6 Suppl):2827-39, 1977.
Montague ED, Gutierrez AE, Barker JL, Tapley ND, Fletcher GH. Conservation surgery and irradiation for the treatment of favorable breast cancer. Cancer, 43(3):1058-61, 1979.
Demonstrated that patients who receive stereotactic radiosurgery for the control of brain metastases may not need additional whole-brain radiation therapy because whole-brain therapy carries a higher risk of affecting learning and memory.
Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009;10(11):1037-1044.
Demonstrated that higher radiation doses delivered using conformal radiation techniques reduce the risk of death from cancer at 10 years after treatment for selected patients with prostate cancer.
Kuban DA, Tucker SL, Dong L, Starkschall G, Huang EH, Cheung MR, Lee AK, Pollack A. Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys 2008;70(1):67-74.
Kuban DA, Levy LB, Cheung MR, Lee AK, Choi S, Frank S, Pollack A. Long-term failure patterns and survival in a randomized dose-escalation trial for prostate cancer. Who dies of disease? Int J Radiat Oncol Biol Phys 2011;79(5):1310-1317.
Invented the concept of varying the intensity of radiation beams by using motorized collimators, which led to the development of a revolutionary mode of radiation therapy: intensity-modulated radiation therapy, in which radiation doses can be tightly conformed in three dimensions to the shape of the tumor.
Bortfeld TR, Kahler DL, Waldron TJ, Boyer AL. X-ray field compensation with multileaf collimators. Int J Radiat Oncol Biol Phys 1994;28(3):723-730.
Demonstrated that radiation therapy can be used effectively for patients with stage I lung cancer who are not fit for surgery, even when the disease is centrally located or recurrent.
Chang JY, Balter PA, Dong L, Yang Q, Liao Z, Jeter M, Bucci MK, McAleer MF, Mehran RJ, Roth JA, Komaki R. Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2008;72(4):967-971.
Kelly P, Balter PA, Rebueno N, Sharp HJ, Liao Z, Komaki R, Chang JY. Stereotactic body radiation therapy for patients with lung cancer previously treated with thoracic radiation. Int J Radiat Oncol Biol Phys 2010;78(5):1387-1393.
Validated and introduced an automated method of contouring tumor and normal tissue volumes on CT scans that simplifies the design of radiation therapy and allows changes in that design during the course of the radiation therapy to compensate for anatomical changes such as tumor shrinkage.
Wang H, Dong L, O’Daniel J, Mohan R, Garden AS, Kian Ang K, Kuban DA, Bonnen M, Chang JY, Cheung R. Validation of an accelerated ‘demons’ algorithm for deformable image registration in radiation therapy. Phys Med Biol 2005;50(12):2887-2905.
Mohan R, Zhang X, Wang H, Kang Y, Wang X, Liu H, Ang KK, Kuban D, Dong L. Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changes. Int J Radiat Oncol Biol Phys 2005;61(4):1258-1266.
Chao KSC, Bhide S, Chen H, Asper J, Bush S, Franklin G, Kavadi V, Liengswangwong V, Gordon W, Raben A, Strasser J, Koprowski C, Frank S, Chronowski G, Ahamad A, Malyapa R, Zhang L, Dong L. Reduce in variation and improve efficiency of target volume delineation by a computer-assisted system using a deformable image registration approach. Int J Radiat Oncol Biol Phys 2007;68(5):1512-1521.
Opened the nation’s most advanced proton therapy facility with the first spot scanning pencil beam capability.
Gillin MT, Sahoo N, Bues M, Ciangaru G, Sawakuchi G, Poenisch F, Arjomandy B, Martin C, Titt U, Suzuki K, Smith AR, Zhu XR. Commissioning of the discrete spot scanning proton beam delivery system at The University of Texas M.D. Anderson Cancer Center, Proton Therapy Center, Houston. Med Phys 2010;37(1):154-163.
Demonstrated for the first time that proton therapy with concurrent chemotherapy can improve the survival of patients with lung cancer while reducing radiation-related toxicity, compared with conventional photon treatment.
Chang JY, Komaki R, Lu C, Wen HY, Allen PK, Tsao A, Gillin M, Mohan R, Cox JD. Phase 2 study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III non-small cell lung cancer. Cancer 2011. [Epub ahead of print; doi: 10.1002/cncr.26080.]