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Clinical Trial Design

Advocated and led the implementation of new ways of designing clinical trials involving Bayesian statistical approaches that allow use of previous data rather than “blinding” all data, thereby speeding up clinical research.

Berry DA. Bayesian clinical trials. Nat Rev Drug Discov. 2006;5(1):27-36.

Developed a response-adaptive randomization design to assign lung cancer patients to effective treatments based on the patient’s biomarker profile.

Zhou X, Liu S, Kim ES, Herbst RS, Lee JJ. Bayesian adaptive design for targeted therapy development in lung cancer – a step toward personalized medicine. Clin Trials. 2008; 5:181-193.


© 2014 The University of Texas MD Anderson Cancer Center