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Cancer Management and Quality of Life

Pioneered ambulatory care of patients undergoing chemotherapy in cost-effective outpatient settings, now standard practice worldwide.

Demonstrated the safe use of chemotherapy pumps and pioneered the provision of anticancer drugs through these pumps at home, at work and while traveling, a practice that has been adopted worldwide.

Kwan JW, Anderson RW. Pharmacist’s knowledge of infusion devices. American Journal of Hospital Pharmacy. 1991;48(10 suppl 1):S52-S53.

Anderson RW. Cytotoxic therapy--developing a home intravenous service. In: Hospital Pharmacy and the Patient: Proceedings of Symposium at the University of York, England, July 7-9, 1982. Bradley T, ed. Boston, MA: MTP Press Limited; 1983:7-15

Began delivering care in multidisciplinary centers in which surgeons, chemotherapists, radiation therapists and others see the patient and decide upon treatment jointly, now a widely adopted best practice.

Pioneered the transfusion of white blood cells into patients with low blood cell counts to prevent infection and the transfusion of platelets into patients with low platelet counts to prevent bleeding, now the standard of therapy worldwide.

Hersh EM, Bodey GP, Nies BA, Freireich EJ. Causes of death in acute leukemia. A ten-year study of 414 patients. JAMA. 1965;193:105-109.

Freireich EJ. Effectiveness of platelet transfusion in leukemia and aplastic anemia. Transfusion. 1966;6:50-54.

Designed continuous-flow blood cell separators to divide whole blood from healthy donors into cellular components; this technique was first used to obtain white blood cells or platelets, then later adapted to collect lymphocytes for immunotherapy and stem cells for bone marrow transplantation.

Freireich EJ, Judson G, Levin RH. Separation and collection of leukocytes. Cancer Res. 1965;25(9):1516-1520.

Levin RH, Whang J, Carbone PP, Freireich EJ. Erythroid homograft following leukocyte transfusion in a patient with acute leukemia. I. Clinical studies and implications. II. Serologic and immunochemical studies. Blood. 1965;26(5):587-609.

McCredie KB, Hersh EM, Freireich EJ. Cells capable of colony formation in the peripheral blood of man. Science. 1971;171(968):293-294.

Pioneered the use of protected environments and prophylactic antibiotic regimens for patients with acute leukemia and other cancers, which greatly reduced life-threatening microbial contamination and infections.

Bodey GP, Freireich EJ, Frei E III. Studies of patients in a laminar air flow unit. Cancer. 1969;24(5):972-980.

Bodey GP, Gehan EA, Freireich EJ, Frei E III. Protected environment - prophylactic antibiotic program in chemotherapy of acute leukemia. Am J Med Sci. 1971;262(3):138-151.

Bodey GP, Rosenbaum B. Effect of prophylactic measures on the microbial flora of patients in protected environment units. Medicine. 1974;53(3):209-228.

Discovered evidence linking precise control of diabetes during therapy with improved survival in patients with leukemia or pancreatic cancer.

Weiser MA, Cabanillas ME, Konopleva M, Thomas DA, Pierce SA, Escalante CP, Kantarjian HM, O’Brien SM. Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen. Cancer. 2004
Mar 15;100(6):1179-85.

Demonstrated that chemotherapy can safely be given after the first trimester to pregnant women with breast cancer.

Hahn KM, Johnson PH, Gordon N, Kuerer H, Middleton L, Ramirez M, Yang W, Perkins G, Hortobagyi GN, Theriault RL. Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer. 2006;107(6):1219-1226.

Invented vascular catheters impregnated with antibiotics that reduce the incidence of bloodstream infections by at least 12-fold and are recommended by the US government for all patients whose catheters must remain in place for more than five days.

Raad I, Darouiche R, Dupuis J, Gabrielli A, Abi-Said D, Hachem R, Wall M, Harris R, Jones J, Buzaid A, Robertson C, Shenaq S, Curling P, Burke T, Ericsson C. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections. A randomized, double-blind trial. The Texas Medical Center Catheter Study Group. Ann Intern Med 1997;127:267-274. 

Hanna H, Benjamin R, Chatzinikolaou I, Alakech B, Richardson D, Mansfield P, Munsell M, Darouiche R, Kantarjian H, Raad I. Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial. J Clin Oncol 2004;22(15):3163-3171.

Ramos ER, Reitzel R, Jiang Y, Hachem RY, Chaftari AM, Chemaly RF, Hackett B, Pravinkumar SE, Nates J, Tarrand JJ, Raad II. Clinical effectiveness and risk of emerging resistance associated with prolonged use of antibiotic-impregnated catheters: more than 0.5 million catheter days and 7 years of clinical experience. Crit Care Med 2011;39(2):245-251.

Developed Abelcet, an antifungal, liposomal-encapsulated agent, for the treatment of potentially life-threatening systemic fungal infections; now approved by the FDA and in wide use.

Lopez-Berestein G, Fainstein V, Hopfer R, Mehta K, Sullivan MP, Keating M, Rosenblum MG, Mehta R, Luna M, Hersh EM, Reuben J, Juliano, RL, Bodey, GP. Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: a preliminary study. J Infect Dis. 1985;151(4):704-710.

Discovered that women with cervical cancer whose treatment five years earlier had included surgery had more satisfactory sexual functioning than those whose treatment included radiation. This research is an example of a new area of study — improving the quality of life for cancer survivors.

Frumovitz M, Sun CC, Schover LR, Munsell MF, Jhingran A, Wharton JT, Eifel P, Bevers TB, Levenback CF, Gershenson DM, Bodurka DC. Quality of life and sexual functioning in cervical cancer survivors. J Clin Oncol. 2005;23(30):7428-7436.

Demonstrated enhanced efficacy of multimodality therapy of desmoid tumors compared to unimodal treatment.

Lev D, Kotilingam D, Wei C, Ballo MT, Zagars GK, Pisters PW, Lazar AA, Patel SR, Benjamin RS, Pollock RE. Optimizing treatment of desmoid tumors.  J Clin Onc. 25:1785-1791, 2007.

Developed organ-preservation techniques for laryngeal cancer involving chemotherapy and radiation therapy instead of laryngectomy and radiation, substantially improving the quality of life for patients by preserving their voice functions.

Hong WK. The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324(24):1685-1690.

Demonstrated that high-dose inhaled steroids stabilize lung function in patients with post-transplantation constrictive bronchiolitis. This nontoxic therapy is effective for a disorder once considered unremitting despite aggressive systemic therapy.

Bashoura L, Gupta S, Jain A, Couriel DR, Komanduri KV, Eapen GA, Safdar A, Broglio KR, Adachi R, Dickey BF.  Inhaled Corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008 Jan;41(1):63-7. Epub 2007 Oct 15.

Pioneered interventional radiology techniques using flexible catheters inserted into major arteries or veins to infuse anticancer drugs directly into tumors to increase antitumor effects and decrease systemic side effects, to inject embolic materials that block the blood supply and starve tumors, or to place stents to reopen narrowed or obstructed tubular anatomic structures.

Wallace S, Charnsangavej C, Carrasco CH, Bechtel W, Wright KC, Gianturco C. Percutaneous transcatheter infusion and infarction in the treatment of human cancer: part I. Curr Probl Cancer. 1984;8(17):1-62.

Wallace S, Carrasco CH, Charnsangavej C, Lee Y-Y, Wright KC, Gianturco C. Percutaneous transcatheter infusion and infarction in the treatment of human cancer: part II. Curr Probl Cancer. 1984;8(18):1-76.

Wallace S, Carrasco CH, Charnsangavej C, Richli WR, Wright K, Gianturco C. Hepatic artery infusion and chemoembolization in the management of liver metastases. Cardiovasc Intervent Radiol. 1990;13(3):153-160.

Wallace MJ, Charnsangavej C, Ogawa K, Carrasco CH, Wright KC, McKenna R, McMurtrey M, Gianturco C. Tracheobronchial tree: expandable metallic stents used in experimental and clinical applications. Work in progress. Radiology. 1986;158(2):309-312.

Demonstrated that practicing yoga techniques during or after cancer therapy can significantly increase physical functioning, reduce fatigue and improve sleep.

Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer. 2004;100(10):2253-2260.

First to demonstrate that gentamicin, an important new antibiotic, could be safely administered intravenously, making it available to many more patients for treatment of serious infections.

Rodriguez V, Stewart D, Bodey GP: Gentamicin sulfate distribution in body fluids. J. Clin. Pharm. Ther 11: 275-281, 1970.  

Bodey GP, Middleman E, Umsawasdi T, Rodriguez V: Intravenous gentamicin therapy for infections in patients with cancer. J Infect Dis S: 174-179, 1971 (Dec)

Invented vascular catheters impregnated with antibiotics that reduce the incidence of bloodstream infections by at least 12-fold and are recommended by the US government for all patients whose catheters must remain in place for more than five days.

Raad I, Darouiche R, Dupuis J, Gabrielli A, Abi-Said D, Hachem R, Wall M, Harris R, Jones J, Buzaid A, Robertson C, Shenaq S, Curling P, Burke T, Ericsson C, and the Texas Medical Center Catheter Study Group. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections.  Ann Intern Med 127:267-274, 1997.

Hanna H, Benjamin R, Chatzinikolaou I, Alakech B, Richardson D, Mansfield P, Munsell M, Darouiche R, Kantarjian H, Raad I.  Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial.  J Clin Oncol 22(15):3163-3171, 2004.

Ramos ER, Reitzel R, Jiang Y, Hachem RY, Chaftari AM, Chemaly RF, Hackett B, Pravinkumar SE, Nates J, Tarrand JJ, Raad II. Clinical effectiveness and risk of emerging resistance associated with prolonged use of antibiotic-impregnated catheters: more than 0.5 million catheter days and 7 years of clinical experience. Crit Care Med 39(2):245-251, 2011.


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