Clinical Cancer Prevention Research Programs
Goals and objectives for the Department of Clinical Cancer Prevention include creating cancer prevention programs in translational research, and expanding the clinical application of basic science, translational, epidemiological and behavioral science research and current research programs in the areas of GI, GU, skin, breast and esophageal carcinogenesis.
Following are descriptions of current research programs in clinical cancer prevention, and the faculty involved in this research.
Actively Accruing Protocols
2006-0521 Phase 1b Randomized, Double-Blinded Placebo-Controlled, Dose Escalation Study of Polyphenon E in Women with a History of Hormone Receptor-Negative Breast Cancer
Principal Investigator: Therese Bevers, M.D.
The goal of this clinical research study is to find the highest tolerable dose of the Polyphenon E (Poly E) that can be given to patients who have had hormone receptor-negative breast cancer. Another goal is to test the safety of Poly E at different dose levels.
DM02-592 Molecular Targeting of 15-LOX-1 for Apoptosis Induction in Human Colorectal Tumors
Principal Investigator: Imad Shureiqi, M.D.
The goal of this clinical research study is to learn how (Celebrex) celecoxib affects polyp cells of the colon and rectum.
Active Protocols
S00-00B Prevention of Cataract and Age-Related Macular Degeneration with Vitamin E and Selenium - SELECT Eye Endpoints (SEE)
Principal Investigator: Elise D. Cook, M.D.
The goal of this clinical research study is to find out if taking Vitamin E and/or selenium can help to prevent cataracts and AMD.
S00-00D A Study of the Effect of Vitamin E and/or Selenium on Adenomatous Colerectal Polyps (ACP) in Participant Enrolled in SELECT Phase III Ancillary to S00-00 (SELECT).
Principal Investigator: Elise D. Cook, M.D.
The overall goal of the SELECT study is to study the effect of selenium and/or Vitamin E on prostate cancer.
The goal of this SELECT side-study is to study the effect of selenium and/or Vitamin E on colorectal cancer. Researchers will look at the results of earlier colon screening exams and tissue collections, in order to check the diagnosis and the effect of the study treatment on colorectal adenoma (CRA). CRA's are tiny growths in the colon that may eventually turn into cancer. During your colon screening procedures, some of these CRAs were removed and stored.