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Fatigue and its Symptom Cluster Related to Inflammatory Cytokine Profiles in Cancer Patients Seeking Emergency Care

Principal Investigator: Xin Shelley Wang, M.D., M.P.H.

About half of cancer patients admitted to the Emergency Center (EC) at MD Anderson Cancer Center have severe levels of fatigue. Although emergency care actively addresses infection and other medical conditions, fatigue is often not addressed. Increased knowledge of the specific mechanisms attributing to fatigue is necessary. However, cancer-related fatigue research is very challenging in terms of its definition and its frequent overlap and clustering with other symptoms.

Specific Goals

  • To describe fatigue severity and its related symptom clusters in cancer patients who are seeking emergency care for fever, pain, shortness of breath or cancer therapy-related gastrointestinal toxicities
  • To describe inflammatory cytokine profiles in cancer patients who are seeking emergency care for fever, pain, shortness of breath or cancer therapy-related gastrointestinal toxicities
  • To determine the type of cytokines that are associated with fatigue severity in cancer patients with the above conditions
  • To assess the impact of fatigue severity on function and health-related quality of life in these patients

Methods

Informed Consent will be obtained and patients will complete the survey. The survey and blood draw will be done within 48 hours of the patient’s EC visit, most likely at triage.

Measures

Measures include the MD Anderson Symptom Inventory (MDASI), Medical Outcomes Study Short Form Health Survey (SF-36) and serum cytokine analysis.

For more information

Contact Xin Shelley Wang, M.D., M.P.H., at swong@mdanderson.org


© 2014 The University of Texas MD Anderson Cancer Center