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Use of Anesthetics with Squirrel Monkeys

Squirrel Monkey Anesthesia

Isoflurane is highly recommended, especially for anesthesia for extended periods (longer than one hour) and for anesthesia of compromised animals.

Animals are easily induced by mask using hand restraint. Induction takes less than two minutes. Induce at 4-5% isoflurane for healthy animals, less for animals that are compromised. Once induced, animals usually may be maintained on 0.5-3% isoflurane. Use low concentration for compromised animals.

Dr. Tim Morris has an excellent publication on intubation of squirrel monkeys.

Reference: Morris, T. H. et al. (1997) An illustrated guide to endotracheal intubation in small non-human primates. Laboratory Animals 31, 157-162.

Long-acting barbiturates, like sodium pentobarbital, are generally only suitable for acute studies. If they must be used for survival studies or extended surgery, they should be used in dilute solution.

For short anesthesia (20 minutes, approximately) ketamine alone at approximately 20-40 mg/kg works well for non-painful procedures such as physical examinations. For painful procedures, xylazine should be given with ketamine at 20 mg/kg ketamine plus 4-6 mg/kg xylazine. We recommend that ketamine and xylazine be given subcutaneously in this small primate to avoid injury to the ischiatic nerve. Injectable anesthetics are not recommended for animals that are sick, injured, of advanced age or otherwise compromised.

For more information, please contact:

Alan Brady D.V.M., ACLAM
Department of Comparative Medicine
Rm 992
USA College of Medicine
Mobile Alabama 36688
Phone 251-460-6239
FAX 251-460-7783

© 2015 The University of Texas MD Anderson Cancer Center