Skip to Content

Metastasis Research Center

The Metastasis Research Program (MRP) is a component of the NIH Cancer Center Support Grant, designed to advance knowledge and research in the field of Metastasis Research. The Metastasis Research Center (MRC), supported by MDACC, is a multidisciplinary research center run in parallel to MRP. The co-directors of the Metastasis Program are Lee Ellis, MD, from the Departments of Surgical Oncology and Cancer Biology, Menashe Bar-Eli, PhD, from the Department of Cancer Biology, and Elsa Flores, PhD, from the Department of Molecular & Cellular Oncology. These investigators also lead the MRC with the addition of Sendurai Mani, PhD, from the Department of Molecular Pathology. Pathology. The MRP/MRC consists of 30+ members from diverse departments contributing their knowledge to the field of metastasis biology. All major tumor sites are included in the MRP/MRC and members of the MRP/MRC are also members of other centers and programs throughout the institute; this leads to cross-fertilization of ideas and resources.


MD Anderson President Ronald DePinho, M.D. and Isaiah J. Fidler, D.V.M, Ph.D. recognize Joan Massagué, Ph.D. of Memorial Sloan-Kettering Cancer Center as keynote speaker at the annual Isaiah J. Fidler Lectureship in Cancer Metastasis Research held Dec. 12, 2011.  Massagué’s talk was titled “Mechanisms of Metastasis.”

The main objectives of the MRP/MRC are to 1) provide educational opportunities in the biology of metastasis, and 2) to provide support for novel research ideas. The MRP/MRC sponsors an annual retreat that is held in early December of each year. The retreat includes presentations from members of the MRP/MRC as well as recipients of grant funding provided by the MRC. The day culminates with the annual Fidler Lectureship in Metastasis Biology that will be selected by members of the MRP/MRC.

In addition, the MRC supports two grant-funding opportunities per year (April and October). Each request for applications (RFA) will be thematic, addressing a distinct area of metastasis research. These grants will be provided for 1-2 years of support with the provision that the recipients of the grant will use these funds to generate preliminary data to support the subsequent submission of an R01 (or equivalent) grant.

The MRP/MRC will consist of subthemes including 1) the tumor microenvironment (led by Dr. Bar-Eli), 2) genomics and genetics of metastasis (led by Dr. Flores), and 3) cancer stem cells and EMT (lead by Dr. Mani). Small working groups will meet to discuss strategies to advance the field in these particular areas.  In addition, each section of the MRP/MRC will alternate in leading Institutional Grand Rounds every 6 months. Lastly, the MRP/MRC will sponsor a seminar series on the first Tuesday of each month.  Designated speakers sponsored by the MRP/MRC will lecture on the topic of metastasis biology.  The MRC seminar series will place a greater emphasis on metastasis research.  Additionally, the remaining Tuesday seminars throughout the month will be sponsored by the Department of Cancer Biology.

 

Lee M. Ellis, M.D., Director

Menashe Bar-Eli, Ph.D., Co-Director

Elsa Flores, Ph.D., Co-Director

Sendurai Mani, Ph.D., Co-Director

 

How to Help Innovative Research 

The institute's interconnected programs offer you a chance to help at an historic moment in the long search for answers to cancer. For more information, send a request to mccombsinstitute@mdanderson.org.





Highlights

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

  • Highlights from the MRC Retreat

MRC Faculty

The Metastasis Research Center is a collaboration of faculty from multiple departments. View a comprehensive list.

Faculty Spotlight:

October 2011 MRC Grant Awardees:
(Development of Genetically Enhanced Mouse Models to better understand cancer metastasis)

George Calin, Ph.D.
Department of Experimental Therapeutics
"Transgenic Mice for LONG1, a Non-Coding RNA Associated with Chromosomal Instability, Metastatic Potential and Resistance to Therapy in Colorectal Cancer"

Jae-Il Park, Ph.D.
Department of Experimental Radiation Oncology
"A Novel Wnt Regulator in Metastatic Colon Cancer"

Dos Sarbassov, Ph.D.
Department of Molecular and Cellular Oncology
"Suppression of Metastasis by the Dominant Active RhoGDI2"


© 2013 The University of Texas MD Anderson Cancer Center