Publications

Clinical Research

Singletary SE, Walsh G, Vauthey JN, Curley SA, Sawaya R, Weber KL, Meric F, Hortobagyi GN. A role for curative surgery in the treatment of selected patients with metastatic breast cancer. Oncologist 2003; 8:241-251.

Makuuchi M, Belghiti J, Belli G, Fan ST, Lau JW, Ringe B, Strasberg SM, Vauthey JN, Yamaoka Y, Yamasaki S. IHPBA concordant classification of primary liver cancer: working group report. J Hepatobiliary Pancreat Surg 2003; 10:26-30.

Esnaola NF, Mirza N, Lauwers GY, Ikai I, Regimbeau JM, Belghiti J, Yamaoka Y, Curley SA, Ellis LM, Nagorney DM, Vauthey JN. Comparison of Clinicopathologic Characteristics and Outcomes after Resection in Patients with Hepatocellular Carcinoma Treated in the United States, France, and Japan. Ann Surg 2003; 238:711-719.

Parikh A, Gentner B, Curley SA, Wu TT, Curley SA, Ellis L M, Vauthey JN. Perioperative complications in patients undergoing major liver resection with and without neoadjuvant chemotherapy. J Gastrointest Surg 2003; 7:1082-1088.

Regimbeau JM, Abdalla EK, Vauthey JN, Lauwers GY, Duran F, Nagorney DM, Ikai I, Yamaoka Y, Belghiti J. Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study. J Surg Oncol 2004; 85(1):36-41.

Smith DL, Soria JC, Morat L, Yang Q, Sabatier L, Liu DD, Nemr RA, Rashid A, Vauthey JN. Human Telomerase Reverse Transcriptase (hTERT) and Ki-67 are Better Predictors of Survival than Established Clinical Indicators in Patients Undergoing Curative Hepatic Resection for Metastatic Colon Cancer. Ann Surg Oncol 2004; 11:45 51.

Pawlik TM, Esnaola NF, Vauthey JN. Surgical treatment of hepatocellular carcinoma: similar long-term results despite geographic variations. Liver Transpl 2004; 10:S74-80.

Clavien PA, Emond J, Vauthey JN, Belghiti J, Chari R, Strasberg SM. Protection of the liver during hepatic surgery. J Gastrointest Surg 2004; 8(3):313-327.

Curley SA, Marra P, Beaty K, Ellis LM, Vauthey JN, Abdalla EK, Scaife C, Raut C, Wolff R, Choi H, Loyer E, Vallone P, Fiore F, Scordino F, De Rosa V, Orlando R, Pignata S, Daniele B, Izzo F. Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Ann Surg 2004; 239(4):450-458.

Abdalla EK, Denys A, Chevalier P, Nemr RA, Vauthey JN. Total and segmental liver volumes: implications for liver surgery. Surgery 2004; 135:404-410.

Vauthey JN, Pawlik TM, Abdalla EL. Arens JF, Nemr RA, Wei SH, Kennamer DL, Ellis LM, Curley SA. Is extended hepatectomy for hepatobiliary malignancy justified? Ann Surg 2004;239(5):722-732.

Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock ,R, Broglio KR, Hess K, Curley SA. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 2004;239(6):818-827.

Patt YZ, Hassan MM, Aguayo A, Nooka AK, Lozano RD, Curley SA, Vauthey JN, Ellis LM, Schnirer II, Wolff RA, Charnsangavej C, Brown TD. Oral capecitabine (Xeloda®)) for treatment of hepatocellular carcinoma, cholangiocarcinoma and gallbladder cancer. Cancer 2004; 101(3):578-586.

Vlastos G, Smith DL, Singletary SE, Mirza NQ, Tuttle TM, Popat RJ, Curley SA, Ellis LM, Roh MS, Vauthey JN. Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastases. Ann Surg Oncol 2004; 11(9):869-874.

Pawlik TM, Poon RT, Abdalla EK, Ikai I, Curley SA, Nagorney DM., Belghiti J, Oi-Lin Ng I, Yamaoka Y, Lauwers GY, Vauthey JN. Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma. J Gastrointest Surg 2004; 8(7):794-805.

Mullen JT, Walsh GL, Abdalla EK, Loyer EM, Curley SA, Vauthey JN. Transdiaphragmatic radiofrequency ablation of liver tumors. J Am Coll Surg 2004; 826-829.

Kobayashi S, Ng CS, Kazama T, Madoff DC, Faria SC, Vauthey JN, Charnsangavej C. Hemodynamic and morphologic changes after portal vein embolization: differential effects in central and peripheral zones in the liver on multiphasic computed tomography. J Comput Assist Tomogr 2004; 28(6):804-810.

Madoff DC, Abdalla EK, Gupta S, Wu TT, Morris JS, Denys A, Wallace MJ, Morello FA Jr, Ahrar K, Murthy R, Lunagomez S, Hicks ME, Vauthey JN. Transhepatic ipsilateral right portal vein embolization extended to segment IV: improving hypertrophy and resection outcomes with spherical particles and coils. J Vasc Interv Radiol 2005; 16:215-225.

Pawlik TM, Poon RT, Abdalla EK, Ikai I, Nagorney DM, Belghiti J, Kianmanesh R, Ng IO, Curley SA, Yamaoka Y, Lauwers GY, Vauthey JN. Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study Surgery 2005; 137:403-410.

Ng KK, Vauthey JN, Pawlik TM, Lauwers GY, Regimbeau JM, Belghiti J, Ikai I, Yamaoka Y, Curley SA, Nagorney DM, Ng IO, Fan ST, Poon RT. Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database. Ann Surg Oncol 2005; 12:364-373.

Pawlik TM, Scoggins CS, Zorzi D, Abdalla EK, Andres A, Curley SA, Loyer EM, Muratore A, Mentha G, Capussotti L, Vauthey JN. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg 2005; 241:715-724.

Dômont J, Pawlik TM, Boige V, Rose M, Weber JC, Hoff PM, Brown TD, Morat L, Pignon JP, Rashid A, Jaeck D, Sabatier L, Elias D, Tursz T, Soria JC, Vauthey JN. The catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: a multicenter analysis. J Clin Oncol 2005; 23:3086-3093.

Pawlik TM, Poon RT, Abdalla EK, Zorzi D, Ikai I, Curley SA, Nagorney DM, Belghiti J, Ng IO, Yamaoka Y, Lauwers GY, Vauthey JN. Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Arch Surg 2005; 140(5): 450-7; discussion 457-8.

Madoff DC, Abdalla EK, Vauthey JN. Portal vein embolization in preparation for major hepatic resection: evolution of a new standard of care? J Vasc Interv Radiol 2005; 16:779-790.

Raut CP, Izzo F, Marra P, et al. Ellis LM, Vauthey JN, Cremona F, Vallone P, Mastro A, Fornage BD, Curley SA. Significant Long-Term Survival After Radiofrequency Ablation of Unresectable Hepatocellular Carcinoma in Patients with Cirrhosis. Ann Surg Oncol 2005; 12(8): 1-13.

Aloia TA, Zorzi D, Abdalla EK, Vauthey JN. Two-surgeon technique for hepatic parenchymal transection using saline-linked cautery and ultrasonic dissection. Ann Surg 2005; 242(2): 172-177.

Poston GJ, Adam R, Alberts S, Curley SA, Figueras J, Haller D, Kunstlinger F, Mentha G, Nordlinger B, Patt Y, Primrose JN, Roh M, Rougier P, Ruers T, Schmoll HJ, Valls C, Vauthey JN, Cornelis M, Kahan JP. OncoSurge: a strategy for long-term survival in liver metastases from colorectal cancer. J Clin Oncol 2005; 23:7125-7134.

Gupta S, Johnson MM, Murthy R, Ahrar K, Wallace MJ, Madoff DC, Rao S, Hicks ME, Vauthey JN, Ajani JA, Yao JC. Hepatic arterial embolization and chemobolization for the treatment of patients with metastatic neuroendocrine tumors: variables affecting response rates and survival. Cancer 2005; 104: 1590-1602.

Pawlik TM, Delman KA, Vauthey JN, Nagorney DM, Oi-Lin Ng I, Ikai I, Yamaoka Y, Belghiti J, Poon RT, Abdalla EK. Tumor size predicts vascular invasion and histologic grade: implications for expanding the criteria for hepatic transplantation. Liver Transpl 2005;11:1086-1092.

Zorzi D, Mullen JT, Abdalla EK, Pawlik TM, Andres A, Muratore A, Curley SA, Mentha G, Capussotti L, Vauthey JN. Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases. J Gastrointest Surg 2006; 10(1): 86-94.

Pawlik TM, Abdalla EK, Ellis LM, Vauthey JN, Curley SA. Debunking dogma: Surgery for four or more colorectal liver metastases is justified. J Gastrointest Surg 2006; 10(2): 240-248.

Pawlik TM, Zorzi D, Abdalla EK, Clary BM, Gershenwald JE, Ross MI, Aloia TA, Curley SA, Camacho LH, Capussotti L, Elias D, Vauthey JN. Hepatic resection for metastatic melanoma: distinct pattern of recurrence and prognosis for ocular versus cutaneous disease. Ann Surg Oncol 2006; (13)5:712-720.

Scaife CL, Ng CS, Ellis LM, Vauthey JN, Charnsangavej C, Curley SA. The accuracy of preoperative imaging of hepatic tumors with helical computed tomography. Ann Surg Oncol 2006; 13(4):542-546.

Bedrosian I, Giacco G, Pederson L, Rodriguez-Bigas MA, Feig B, Hunt KK, Ellis L, Curley SA, Vauthey JN, Delclos M, Crane C, Janjan N, Skibber JM. Outcome after curative resection for locally recurrent rectal cancer. Dis Colon Rectum 2006; 49: 175-182.

Zorzi D, Abdalla EK, Pawlik TM, Brown TD, Vauthey JN. Subtotal hepatectomy following neoadjuvant chemotherapy for a previous unresectable hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 2006;13:347-350.

Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, Xiong HQ, Eng C, Lauwers GY, Mino-Kenudson M, Risio M, Muratore A, Capussotti L, Curley SA, Abdalla EK. Chemotherapy regimen predicts steatohepatitis and an increase in ninety-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006; 24(13):2065-2072.

Aloia TA, Vauthey JN Loyer EM, Ribero D, Pawlik TM, Wei SH, Curley SA, Zorzi D, Abdalla EK. Solitary colorectal liver metastasis: resection determines outcome Arch Surg 2006; 141:460-467.

Abdalla EK, Eng C, Madary A, Vauthey JN. Southwest Oncology Group 0408: Phase II trial of neoadjuvant capecitabine/oxaliplatin/bevacizumab for resectable colorectal metastases in the liver. Clin Colorectal Cancer 2006; 5:436-439.

Pawlik TM, Vauthey JN, Abdalla EK, Pollock R, Ellis LM, Curley SA. Results of a single-center experience with resection and ablation for sarcoma metastatic to the liver. Arch Surg 2006; 141:537-543.

Abdalla EK, Adam R, Bilchik AJ, Jaeck D, Vauthey JN, Mahvi D. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 2006; (13)10:1271-1280.

Donadon M, Vauthey JN, Loyer EM, Charnsangavej C, Abdalla EK. Portal thrombosis and steatosis following preoperative chemotherapy with folfiri and bevacizumab for colorectal liver metastases. World J Gastroenterol 2006; 12(40):6556-6558.

Colon Cancer Angiogenesis

Shaheen, R.M., Liu, W., Davis, D.W., Wilson, M.R., McMahon, J., McConkey, D.J., Ellis, L.M. A Tyrosine Kinase Inhibitor to the Vascular Endothelial Growth Factor Receptor Inhibits Angiogenesis and Growth of Colon Cancer Liver Metastases. Surgical Forum. In Press, 1999.

Zebrowski, B.K., Liu, W., Ramirez, K., Akagi, Y., Mills, G., Ellis, L.M. Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites. Annals of Surgical Oncology, 6(4):373-378, 1999.

Akagi, Y. Liu, W., Zebrowski, B. Xie, K., Ellis, L.M. Regulation of Vascular Endothelial Growth Factor in Human Colon Cancer by Insulin-like Growth Factor-I. Cancer Res, 58:4008-4014, 1998.

Akagi, Y., Liu, W., Xie, K., Zebrowski, B., Shaheen, R.M., Ellis, L.M.: Regulation of Vascular Endothelial Growth Factor Expression in Human Colon Cancer by Interleukin-1 Beta. British Journal of Cancer, In Press, 1999.

Ellis, L.M., Staley, C.A., Liu, W., Fleming, R.Y.D., Parikh, N.U., Bucana, C.D., Gallick, G.E. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. J. Biol. Chem., 273(2):1052-1057, 1998.

Takahashi, Y., Bucana, C.D., Cleary, K.R., Ellis, L.M. p53 vessel count, and vascular endothelial growth factor expression in human colon cancer. Int. J. Cancer, 79, 34-38, 1998.

Takahashi, Y., Kitadai, Y., Bucana, C., Cleary, K.R., Ellis, L.M. Expression of vascular endothelial growth factor and its receptor (KDR) correlates with vascularity, metastasis and proliferation of human colon cancer. Cancer Res., 55:3964-3968, 1995.

Takahashi, Y., Tucker, S.L., Kitadai, Y., Koura, A.N., Bucana, C.D., Cleary, K.R., Ellis, L.M. Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch. Surg., 132:541-546, 1997.

Portera, C.A., Berman, R.S., Ellis, L.M., Molecular determinants of colon cancer metastasis. Surgical Oncology. In Press, 1999.

Fidler, I.J., Kumar, R., Bielenberg, D.R., Ellis, L.M. Molecular determinants of angiogenesis in cancer metastasis. The Cancer J Sc Am., 4(Suppl 1):S58-S66, 1998.

Ellis, L.M., Walker, R.A., Gasparini, G. Is determination of angiogenic activity in human tumours clinically useful? European Journal of Cancer 34:5:609-618, 1998.

Ellis, L.M., Fidler, I.J. Angiogenesis and metastasis. Eur. J. Cancer, 32A(14):2451-2460, 1996.

Radinsky, R., Ellis, L.M. Molecular determinants in the biology of liver metastasis. Surg. Onc. Clin. North Am., 5:215-229, 1996.

Ellis, L.M., Radinsky, R., Fidler, I.J. Recent advances in the biology of cancer invasion and metastasis. In: Bland (ed.), Surgical Oncology: Contemporary Principles and Practice. Appleton and Lange Publishers, Inc. In Press, 1999.

Growth Factors & Metastasis

Radinsky, R. Growth factors and their receptors in metastasis. Semin. Cancer Biol., 2:169-177, 1991.

Radinsky, R., Weisberg, H.Z., Staroselsky, A.N., Fidler, I.J. Expression level of the NM23 gene in clonal populations of metastatic murine and human neoplasms. Cancer Res. (Adv. in Brief), 52:5808-5814, 1992.

Radinsky, R., and Fidler, I.J. Growth regulation at organ-specific metastases. In Vivo, 6:325-332, 1992.

Radinsky, R., Bucana, C.D., Ellis, L.M., Sanchez, R., Cleary, K.R., Brigati, D.J., Fidler, I.J. A rapid colorimetric in situ mRNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas. Cancer Res. (Adv. in Brief), 53:937-943, 1993.

Bucana, C.D., Radinsky, R., Dong, Z., Sanchez, R., Brigati, D., and Fidler, I.J. A rapid colorimetric in situ mRNA hybridization technique using hyperbiotinylated oligonucleotide probes for analysis of mouse mdr 1 in colon carcinoma cells. J. Histochem. Cytochem. (Rapid Publication), 41:499-506, 1993.

Radinsky, R. Paracrine growth influences of human colon carcinoma metastasis. Cancer Metastasis Rev., 12:345-361, 1993.

Dong, Z., Radinsky, R., Fan, D., Tsan, R., Bucana, C.D., Wilmanns, C., Fidler, I.J. Organ-specific modulation of steady-state mdr-1 gene expression and drug resistance in murine colon cancer cells. J. Natl. Cancer Inst. 86:913-920, 1994.

Radinsky, R., Risin, S., Fan, D., Dong, Z., Bielenberg, D., Bucana, C.D., and Fidler, I.J. Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clinical Cancer Res., 1:19-31, 1995.

Radinsky, R. Modulation of Tumor Cell Gene Expression and Phenotype by the Organ-Specific Metastatic Environment. Cancer and Metastasis Reviews 14:323-338, 1995.

Kitadai, Y., Radinsky, R., Bucana, C.D., Takahahi, Y., Xie, K., Tahara, E., Fidler, I.J. Regulation of CEA Expression in Human Colon Carcinoma Cells by the Organ Microenvironment. Am. J. Pathol. 149:1157-1166, 1996.

Fidler, I.J. Radinsky, R. Editorial: The Search for Genes that Suppress Cancer Metastasis. J. Nat. Cancer Inst. 88:1700-1703, 1996.

Singh, R. K., Tsan, R., Radinsky, R. Influence of the Host Microenvironment on the Clonal Selection of Human Colon Carcinoma Cells During Primary Tumor Growth and Metastasis. Clin. Expt. Metastasis. 15:140-150, 1997.

Parker, C., Roseman, B.J., Bucana, C.D., Tsan, R., Radinsky, R. Preferential Activation of Epidermal Growth Factor Receptor in the Human Colon Carcinoma Liver Metastases Growing in Nude Mice. J. Histochem and Cytochem., 46:595-602, 1998.

Biology of Colon Cancer Metastasis to the Liver

Kitadai Y, Ellis LM, Takahashi Y, Bucana CD, Anzai H, Tahara E, Fidler IJ. Multi-parametric in situ messenger RNA hybridization analysis to detect metastasis-related genes in surgical specimens of human colon carcinomas. Clin Cancer Res Oct; 1(10):1095-102, 1995.

Shinohara H, Killion JJ, Kuniyasu H, Kumar R, Fidler IJ. Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002. Clin Cancer Res Sep;4(9):2053-63, 1998.

Kitadai Y, Ellis LM, Tucker SL, Greene GF, Bucana CD, Cleary KR, Takahashi Y, Tahara E, Fidler IJ Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma. Am J Pathol Nov;149(5):1541-51, 1996.

Kitadai Y, Radinsky R, Bucana CD, Takahashi Y, Xie K, Tahara E, Fidler IJ Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment. Am J Pathol Oct;149(4):1157-66, 1996.

Takahashi Y, Ellis LM, Wilson MR, Bucana CD, Kitadai Y, Fidler IJ. Progressive upregulation of metastasis-related genes in human colon cancer cells implanted into the cecum of nude mice. Oncol Res;8(4):163-9, 1996.

Gutman M, Fidler IJ Biology of human colon cancer metastasis. World J Surg Mar-Apr;19(2):226-34, 1995.

Gutman M, Singh RK, Price JE, Fan D, Fidler IJ Accelerated growth of human colon cancer cells in nude mice undergoing liver regeneration. Invasion Metastasis; 14(1-6):362-71, 1995-95.

Fabra A, Nakajima M, Bucana CD, Fidler IJ. Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice. Differentiation Dec;52(1):101-10, 1992.

Wilmanns C, Fan D, O'Brian CA, Bucana CD, Fidler IJ Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer 1992 Aug 19;52(1):98-104 Cancer Metastasis Rev Oct;10(3):229-43, 1991.

Fidler IJ Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis. J Natl Cancer Inst Dec 19;82(24):1890-8, 1990.

Nakajima M, Morikawa K, Fabra A, Bucana CD, Fidler IJ Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst Mar 21;82(6):517-22, 1990.

Morikawa K, Morikawa R, Killion JJ, Fan D, Fidler IJ Isolation of human colon carcinoma cells for resistance to a single interferon associated with cross-resistance to multiple recombinant interferons: alpha, beta, and gamma

Jessup JM, Giavazzi R, Campbell D, Cleary KR, Morikawa K, Hostetter R, Atkinson EN, Fidler IJ Metastatic potential of human colorectal carcinomas implanted into nude mice: prediction of clinical outcome in patients operated upon for cure. Cancer Res Dec 15;49(24 Pt 1):6906-10, 1989.

Schackert HK, Fidler IJ Development of an animal model to study the biology of recurrent colorectal cancer originating from mesenteric lymph system metastases. Int J Cancer Jul 15;44(1):177-81, 1989.

Morikawa K, Fidler IJ Heterogeneous response of human colon cancer cells to the cytostatic and cytotoxic effects of recombinant human cytokines: interferon-alpha,

interferon-gamma, tumor necrosis factor, and interleukin-1. J Biol Response Mod Apr;8(2):206-18, 1989.

Morikawa K, Fan D, Denkins YM, Levin B, Gutterman JU, Walker SM, Fidler IJ Mechanisms of combined effects of gamma-interferon and 5-fluorouracil on human colon cancers implanted into nude mice. Cancer Res Feb 15;49(4):799-805, 1989.

Signal Transduction of Colon Cancer Liver Metastasis

Han NM, Curley SA, Gallick GE Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. Clin Cancer Res Aug;2(8):1397-404, 1996.

Han NM, Fleming RY, Curley SA, Gallick GE Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol Apr-May;4(3):264-8, 1997.

Staley CA, Parikh NU, Gallick GE Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. Cell Growth Differ Mar;8(3):269-74, 1997.

Termuhlen PM, Curley SA, Talamonti MS, Saboorian MH, Gallick GE Site-specific differences in pp60c-src activity in human colorectal metastases. J Surg Res Apr;54(4):293-8, 1993.

Talamonti MS, Roh MS, Curley SA, Gallick GE Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest Jan;91(1):53-60, 1993.

Jessup JM, Gallick GE The biology of colorectal carcinoma. Curr Probl Cancer Sep-Oct;16(5):261-328, 1992.

Novotny-Smith CL, Gallick GE Growth inhibition of human colorectal carcinoma cell lines by tumor necrosis factor-alpha correlates with reduced activity of pp60c-src. J Immunother Apr;11(3):159-68, 1992.

Garcia R, Parikh NU, Saya H, Gallick GE Effect of herbimycin A on growth and pp60c-src activity in human colon tumor cell lines. Oncogene Nov;6(11):1983-9, 1991.

Gallick GE, Kurzrock R, Kloetzer WS, Arlinghaus RB, Gutterman JU Expression of p21ras in fresh primary and metastatic human colorectal tumors. Proc Natl Acad Sci U S A Mar;82(6):1795-9, 1985.