Institute for Applied Cancer Science
James Horner - Associate Director, Mouse Cancer Models
Together with Ronald DePinho, M.D., James Horner, B.S. and his facility staff have a long record of mouse engineering and phenotypic characterization of cancer-prone strains. More than 20 years ago, they established the first National Cancer Institute-supported shared transgenic and gene targeting facility at the Albert Einstein College of Medicine. Using early technologies, they generated more than 2,000 different transgenic mouse strains and approximately 200 germline mutant strains for more than 55 different laboratories.
At the Dana-Farber Cancer Institute, this effort was continued with the production of many hundreds of germline transgenic and knock-out/knock-in alleles, the design of which are, on average, far more complex than early generation alleles in the 1990s.