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Mouse Models of Human Cancer

Mouse Models of Human Cancer are genetically altered mice designed to mimic the mutations that occur in human cancers. The mouse provides a powerful mammalian experimental system to elucidate the mechanisms of cancer initiation, maintenance, progression and as a platform for preclinical drug development.

The IACS Mouse Modeling Team provides expertise in all areas of model generation from sophisticated design, molecular biology and cell culture to embryo manipulation. The Mouse Modeling Team adapts and optimizes state of the art technologies to accelerate the generation of multi-allele mouse cancer models. As part of MD Anderson, the Mouse Modeling Team collaborates with investigators from a broad range of departments and is well positioned to access the latest data identifying new therapeutic targets to quickly generate models of new targets in the correct mutational background.

James Horner, who has generated more than 2,000 different transgenic mouse strains over his career, leads the IACS Mouse Modeling Team.

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Institute for Applied Cancer Science
MD Anderson Cancer Center
1901 East Road
Houston TX 77054
Tel: 713-745-2600

For questions concerning collaborations or partnerships, please contact:

Eric Devroe
Executive Director of Strategic Alliances
EJDevroe@mdanderson.org

We need your help

Philanthropic support will provide IACS several critical advantages that will ultimately benefit cancer patients by providing them with novel treatments in a shorter timeframe. If you’re interested in advancing this transformative venture, please donate through the myGiving site.


© 2013 The University of Texas MD Anderson Cancer Center