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M. James You, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

  • Tumor suppressors
  • Genetically engineered mouse models
  • Translational pathology

My laboratory is interested in cancer biology and genetics as well as translational research. Our current focus is myeloid and lymphoid neoplasm using genetic and oncogenomic approaches to uncover important genetic events that may drive tumor initiation and progression. Approaches include Cre / Lox- and Flp / FRT-based conditional systems to generate genetically engineered mouse models, including Pten and Ink4a/Arf deficient acute leukemia, which permits studies of the underlying biology and mechanisms of various tumor types. In addition, we complement basic mechanistic studies with translational research on human tumor specimens, which helps to correlate genetic changes, expression profiling, or other molecular signatures with clinical behavior and outcome.

Contact Information

Phone:  (713) 745-1657
Email:  mjamesyou@mdanderson.org

Publications

1.    You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, DePinho RA. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.  Proc Natl Acad Sci 2002; 99:1455-60.

2.    Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, Depinho RA. Cooperative action of p53 and Pten in normal and neoplastic stem/progenitor cell differentiation and in primary glioblastoma. Nature. 2008; 455:1129-33.

3.    He H, Wang Y, Guo X, Ramchandani MJ, Shen MF, Garcia DA, Deng Y, Multani AS, You MJ, Chang S. Pot1b deletion and telomerase haploinsufficiency elicit phenotypes resembling Dyskeratosis Congenita. Mol Cell Biol. 2009; 29:229-40.

4.    Dankort D, Curley DP, Cartlidge RA, Nelson B, You MJ, Depinho RA, McMahon M, Bosenberg M. BRafV600E cooperates with Pten silencing to induce metastatic melanoma. Nature Genetics. 2009; 41:544-52.

5.    You, MJ.  Mouse Models of Lymphoma and Lymphoid Leukemia. Neoplastic Hematopathology: Experimental and Clinical Approaches (in the series of Hematology by the Humana Press, Inc. 2010).

6.    Medyouf, H, Gao, X, Gusscott, S, Liu, Q, Matherly, LH, Gerby, B, Pflumio, F, Schultz, K, Chen, Ling C, You, MJ *, Weng,  AP *. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN loss. Blood. 2010; 115:1175-84. (*co-corresponding authors).


© 2012 The University of Texas MD Anderson Cancer Center