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M. James You, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

  • Tumor suppressors
  • Genetically engineered mouse models
  • Translational pathology

My laboratory is interested in cancer biology and genetics as well as translational research. Our current focus is myeloid and lymphoid neoplasm using genetic and oncogenomic approaches to uncover important genetic events that may drive tumor initiation and progression. Approaches include Cre / Lox- and Flp / FRT-based conditional systems to generate genetically engineered mouse models, including Pten and Ink4a/Arf deficient acute leukemia, which permits studies of the underlying biology and mechanisms of various tumor types. In addition, we complement basic mechanistic studies with translational research on human tumor specimens, which helps to correlate genetic changes, expression profiling, or other molecular signatures with clinical behavior and outcome.

Contact Information

Phone:  (713) 745-1657


View a complete list of publications.

© 2015 The University of Texas MD Anderson Cancer Center