Bin Wang, Ph.D.
Present Title & Affiliation
Assistant Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
- Genomic instability
- DNA damage response
- Tumor suppressors
Defects in the ability of cells to properly respond to and repair DNA damage result in genomic instability and underlie many forms of cancer. The DNA damage response is a complex signaling network that coordinates cell cycle arrest, DNA repair, transcription, apoptosis and other cellular processes in response to genotoxic stress. Mutations that impair the functions of this signaling pathway are often associated with cancer predisposition syndromes (e.g. p53, Brca1, Brca2 and Chk2 mutations). The goal of our research is to understand how cells respond to DNA damage and safeguard the integrity of the genome.
We are currently investigating several key players in the DNA damage response pathway. We are interested in using various genetic approaches, such as gene knockouts, microarray, Chip-seq and genetic screens using siRNA libraries, to identify important players in the DNA damage response and define the roles of these proteins in maintaining genomic stability and tumor suppression.
View a complete list of publications.