Angabin Matin, Ph.D.
Present Title & Affiliation
Associate Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
- Germ cell tumors
- RNA metabolism
- Mouse models
The overall goal of my research is to identify genes responsible for mutant phenotypes in the mouse and, at the same time, to define new mouse models. As part of our positional cloning and phenotyping projects, we study spontaneous mouse mutations with skin phenotypes, trying to identify genes important to skin and hair follicle biology. We have shown that one of theses mutations (nackt) includes a deletion in the cathepsin L gene, and found that CTSL is important for hair follicle morphogenesis and epidermal differentiation. Using this model, we found a paradoxical protective role of CTSL in mouse skin carcinogenesis.
We also have identified two spontaneous recessive mutations that affect the Ass1 (argininosuccinate synthetase 1) gene. The phenotype of homozygous mice includes severe retardation in post-natal development, alopecia with scaly skin, ataxia and circling behavior (a complex phenotype that is virtually identical to the human Citrullinemia type I). Citrullinemia type I is a rare inherited disorder caused by deficiency of the ASS enzyme. In addition, we have successfully identified the luca mutation (loss of hair and irritated skin) as a premature stop codon in the Zdhhc13 gene. Another project deals with the development of a new genetically defined hairless inbred strain (SKHIN). This will represent a unique tool for the study of the underlying genetic basis of UV-induced skin carcinogenesis.
These projects involve collaborations the Carcinogenesis Department and with the Pasteur Institute in France. As the Director of the Genetics Service of the CCSG Research Animal Support Facility – Smithville, I advise and coordinate speed congenic projects, genetic monitoring, background characterizations and whole genome scans for MD Anderson faculty.
View a complete list of publications.