Randy J. Legerski, Ph.D.
Present Title & Affiliation
Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
- DNA repair mechanisms
- Cell cycle responses to DNA damage
- Tumor suppression
Repair of interstrand cross-links is a significant topic for human health since important chemotherapeutic agents used against cancer and other diseases induce these lesions, and an understanding of these mechanisms can lead to improved therapies. We study molecular mechanisms of cellular responses to genotoxic damage and mechanisms of genomic stability in mammalian systems.
We are particularly interested in the relationship between these pathways and the degenerative processes of carcinogenesis and aging in humans. One current focus is on the mechanisms of repair of interstrand cross-links in DNA. A second focus is on cell cycle pathways that respond to genotoxic agents such as checkpoints. In this area we focus on the small gene family SNM1 that includes the genes SNM1A, SNM1B/Apollo and Artemis. These genes are involved in many aspects of cell cycle regulation in response to genotoxic agents.
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