Vicki Huff, Ph.D.
Present Title & Affiliation
Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
- Cancer predisposition and etiology
- Mouse models of human disease
- Kidney development
My research interests broadly revolve around the genetics of human disease and, more specifically, cancer. To this end I have an active research program in the molecular genetics of Wilms tumor (WT) including the molecular analysis (e.g., gene mutation, gene expression, protein expression) of tumors, localization and identification of WT familial predisposition genes, and the development and use of an endogenous tumor mouse model for WT.
A mouse genome provides us with tools to understand the progression of premalignant lesions to malignant tumors and to investigate the functional significance of molecular alterations observed in human tumors. The Wt1-Igf2 mouse exhibits upregulation of the IGFR1 pathway which is observed in a majority of human cancers and which is a promising therapeutic target now being investigated in phase II clinical trials.
Thus, the Wt1-Igf2 mouse may provide an excellent and relevant model for studying the pathobiology of tumor response, nonresponse and relapse. Our laboratory also investigates the role of WT1 itself -- its downstream targets, its protein interaction partners, etc. -- in both kidney development and tumorigenesis.
View a complete list of publications.