Gilbert Cote, Ph.D.
Present Title & Affiliation
Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
- Cancer spliceosome
- Genomewide splicing
- Glioblstoma models
We explore the role of genetics in the prediction of cancer outcomes and work to identify new therapeutic targets. To that end, our group examines the components of the cancer spliceosome and how changes in splicing factor expression contributes to tumorigenesis. Our primary model has been to look at genomewide splicing in glioblastoma in response to knockdown of splicing factors in cell line models. We have used several array-based methods to identify changes that translate to patient samples.
We have also maintained long-term interest in the genetics of hereditary endocrine cancer syndromes. A recent focus has been on examination of genetic changes associated with familial and sporadic medullary thyroid cancer. We are using array-based studies to help identify tumor suppressor genes and oncogenes that may contribute to the progress of this disease. Our goals are to define the role of genetics in the prediction of cancer outcomes and is to identify new targets that can be considered therapeutically.
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