Center for Cancer Epigenetics
The Center for Cancer Epigenetics (CCE) brings together faculty members focused on epigenetics, the study of heritable and acquired changes that affect gene expression and cellular differentiation without DNA sequence alteration. The CCE is directed by Sharon Dent, Ph.D.
Epigenetic changes are now thought to be just as important as gene mutations in cancer development. The ultimate goal of the center is to define the full spectrum of epigenetic changes that occur in cancers, to discover the molecular causes of these changes, and to translate that newly gained knowledge into the clinic in the form of novel, epigenetic based therapies. Members of the center include faculty from several basic research and clinical departments at MDACC, including our Smithville campus, as well as Baylor College of Medicine. Information and ideas are exchanged through weekly seminars and a monthly Distinguished Lecturer series. For more information regarding our research programs, use the faculty link on this page, then click on each member's name to see individual research interests.
What is Epigenetics? (pdf)
Interview with Dr. Jean-Pierre Issa on epigenetic therapy