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Gladden Laboratory


 Cells must be able to sense neighboring cells and the surrounding environment to organize into tissues and organs in the mammalian body.  How cells sense and communicate with adjacent cells is a fundamental question being asked in the Gladden lab.  In particular, we study how cell adhesion and cell polarity are intertwined in normal tissue development and how these pathways are altered in diseases such as cancer.

 

             
Intestinal cysts grown in 3D cultures organize into polarized spheres in normal cells (left) but cannot form organized cysts (right) if cell polarity or cell adhesion are compromised

© 2014 The University of Texas MD Anderson Cancer Center