Interventional Radiology Faculty
Sanjay Gupta, MD, D.N.B
Hepatic Arterial Embolization with Doxorubicin-Loaded Superabsorbent Polymer Microspheres in a Rabbit Liver Tumor Model
Cardiovasc Intervent Radiol. 2011 Oct;34(5):1021-30. doi: 10.1007/s00270-011-0154-6. Epub 2011 Apr 9.
Effects of Near-infrared Laser Irradiation of Biodegradable Microspheres Containing Hollow Gold Nanospheres and Paclitaxel Administered Intraarterially in a Rabbit Liver Tumor Model
J Vasc Interv Radiol. 2012 Apr;23(4):553-61. doi: 10.1016/j.jvir.2011.12.017. Epub 2012 Feb 15.
Tumor uptake of hollow gold nanospheres after intravenous and intra-arterial injection: PET/CT study in a rabbit VX2 liver cancer model
Mol Imaging Biol. 2013 Oct;15(5):614-24. doi: 10.1007/s11307-013-0635-x.
Developing novel interventional techniques focusing on targeted drug delivery methods (e.g. drug-eluting beads and nanoparticles) for local and regional treatment of cancers.
Ongoing Clinical Projects
To study the presentation, endovascular management, outcome, and effect on renal function of selective transarterial embolization of renal artery pseudoaneurysms and arteriovenous (AV) fistulae in patients following open or laparascopic partial nephrectomy. (PI)
To evaluate the frequency of use, indications, and safety of retrievable-type inferior vena cava (IVC) filters at a tertiary care cancer center. (CoPI)
To evaluate the effect of coaxial guide needle size (18 vs. 19 gauge) on the risk of pneumothorax and chest tube placement after CT-guided lung biopsy. (PI)
To evaluate the role combined ablation – chemoembolization for liver tumors. (PI)
Ongoing Pre-Clinical Translational Projects
Electroporation Induced Intracellular Delivery of Nanoparticles (Copper Sulfide, gold nanoshells, micelles) loaded with therapeutic siRNA and chemotherapeutic agents (PI)
NIR-gold nanoshell mediated chemo- photothermal therapy for liver tumors (Co-PI)
CT Imaging of Liver Tumors using NCTX-150 (Blood pool contrast agent): Pilot Study in a Rabbit Model (PI)