Nianxiang Zhang, Ph.D.

Senior Statistical Analyst

Degrees

M.S. in Biostatistics, The University of Texas School of Public Health, Houston, TX
Ph.D. in Molecular Biology, National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, Beijing, China

Areas of Interest

Prospective and retrospective study design
Statistical Analysis
Statistical Programming

Publications

Heltemes-Harris LM, Willette MJL, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Koeuth T, Grosschedl R, Busslinger M, Kitamura D, Gillespie EC, Kornblau SM, Farrar MA. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med (in press)

The Cancer Genome Atlas Research Network (with Zhang N as a listed coauthor). Integrated genomic analyses of ovarian carcinoma. Nature (in press)

Kornblau SM, Coombes KR, Zhang N. Use of RPPA to Study Protein Expression in Leukemia: Technical and Methodological Lessons Learned. Ed: Ulrike Korf. (in press)

Starkova J, Gadgil S, Qiu YH, Zhang N, Hermanova I, Kornblau SM, Drabkin HA. Upregulation of homeodomain genes, DLX1/2, by FLT3 signaling. Haematologica. 2011 Feb 28 [Epub ahead of print]

Carter BZ, Qiu YH, Zhang N, Coombes KR, Mak DH, Thomas DA, Ravandi F, Kantarjian HM, Koller E, Andreeff M, Kornblau SM. Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML. Blood. 2011; 117(3):780-7

Yang L, Wang H, Kornblau SM, Graber DA, Zhang N, Matthews JA, Wang M, Weber DM, Thomas SK, Shah JJ, Zhang L, Lu G, Zhao M, Muddasani R, Yoo SY, Baggerly KA, Orlowski RZ. Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma. Oncogene. 2011; 30(11):1329-40.

Kornblau SM, Singh N, Qiu Y, Chen W, Zhang N, Coombes KR. Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia. Clin Cancer Res. 2010; 16:1865-74.

Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, Zhang N, Liang S, Donehower LA, Issa JP. Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res. 2010; 20:332-40.

Zhang N, Kaur R, Akter S, Legerski RJ. Cdc5L mediated ATR activation in S-phase checkpoint. EMBO Reports. 2009; 10(9):1029-35.

Poland KS, Shardy DL, Azim M, Naeem R, Krance RA, Dreyer ZE, Neeley ES, Zhang N, Qiu YH, Kornblau SM, Plon SE. Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia. Genes Chromosomes Cancer. 2009; 48:480-9.

Wei C, Amos CI, Zhang N, Zhu J, Wang X, Frazier ML. Suppression of pancreas tumor by targeting mTOR signaling. Cancer Lett. 2009; 277(2):149-54.

Bae J-B, Mukhopadhyay S, Liu L, Zhang N, Tan J, Liu X, Shen X, Li L, Legerski R. Snm1B/Apollo Mediates Replication Fork Collapse and S Phase Checkpoint Activation in Response to DNA Interstrand Cross-Links. Oncogene. 2008; 27(37):5045-56.

Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mTOR signaling. Clin Cancer Res. 2008; 14:1167-71.

Zhang N, Lu X, Liu X, Legerski RJ. Cooperation of FA, Rev3 and Mismatch Repair pathway proteins in promoting homologous recombination induced by Interstrand Crosslinks. DNA Repair (Amst). 2007; 6(11):1670-8

Zhang N, Kaur R, Lu X, Shen X, Li L, Legerski RJ. The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. J Biol Chem. 2005; 280(49):40559-67

Lu X, Zhang N, Vasquez K, Barton M, Legerski R. Repair of psoralen interstrand cross-links in Xenopus laevis egg extracts is highly mutagenic. Biochem Biophys Res Commun. 2005; 336(1):69-75.

Ahkter S, Richie CT, Zhang N, Behringer RR, Zhu C, Legerski RJ. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol. 2005; 25(22):10071-8.

Zhang N, Lu X, Legerski R. Partial reconstitution of human interstrand cross-link repair in vitro: characterization of the roles of RPA and PCNA. Biochem Biophys Res Commun. 2003; 309:71-8.

Zhang N, Lu X, Zhang X, Peterson C, Legerski R. hMutS-beta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro. Mol Cell Biol. 2002; 22:2388-97.

Zhang N, Zhang X, Peterson C, Li L, Legerski R. Dfferential processing of UV mimetic and interstrand crosslink damage by XPF cell extracts. Nucleic Acid Res. 2000; 28:4800-04.

Zhang N, Li J, Wang C. GroEL and protein disulfide isomerase each binds with folding intermediates of D-glyceraldehyde-3-phosphate dehydrogenase released from complexes formed with the other. J Protein Chem. 2000; 19:569-574.

Zhang N, Wang C. A stable cold folding intermediate of rabbit muscle D-glyceraldehyde 3-phosphate dehydrogenase. Eur J Biochem 1999; 264:1002-8.

^{Updated May 24, 2011}