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Conference Program

Saturday, May 10, 2014

7:00 a.m.   Registration 

8:00 – 8:30 a.m.   Welcome

Guo-Qiang Chen
Shanghai Jiao Tong University, Shanghai, China

Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, Texas

Jinke Cheng
Shanghai Jiao Tong University, Shanghai, China

8:30 - 9:45 a.m.   Session I 

Moderator: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, Texas

8:30 - 8:55 — Induction of oncoprotein degradation as a targeted therapy for leukemia and beyond
Chen Zhu
Shanghai Jiao Tong University School of Medicine, Shanghai, China

8:55 - 9:20 — The ubiquitin proteolytic signal is far broader than we thought: Novel biological lessons learnt for the NF-κB activation pathway
Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel

9:20 - 9:45 — Global control of sumoylation by PML: role in oxidative stress response and APL cure
Hughes de The
University of Paris, Paris, France

9:45 - 10:15 a.m.   Break

10:15 a.m. – 12:00 p.m.   Session II

Moderator: Guo-Qiang Chen
Shanghai Jiao Tong University, Shanghai, China

10:15 - 10:40 — SUMO: Implications for Human Diseases
Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, Texas

10:40 - 11:05 — SENP2 in atherosclerosis
Jun-ichi Abe
University of Rochester, Rochester, New York

11:05 - 11:30 — SENP1 in diabetes
Patrick E. MacDonald
University of Alberta, Edmonton AB, Canada

11:30 - 11:45 — SUMO-1 as novel therapy for Heart Failure
Changwon Kho
Icahn School of Medicine at Mount Sinai, New York, New York

11:45 - 12:00 — PIAS1 as a therapeutic target for Huntington's disease
Joseph Ochaba
University of California, Irvine, California

12:00 p.m. - 1:00 p.m.   Lunch

1:00 - 2:25 p.m.   Session III

Moderator: Hsing-Jien Kung
National Health Research Institute, Taipei, Taiwan

1:00 - 1:25 — Regulation of the Fanconi Anemia/BRCA Pathway by SUMO
Alan D'Andrea
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts

1:25 - 1:40 — Elg1, a SUMO-interacting protein that maintains genome stability
Martin Kupiec
Tel Aviv University, Tel Aviv, Israel

1:40 - 1:55 — SUMO and ubiquitin orchestrate the distinct functions of SLX4 complex in DNA damage repair
Jian Ouyang
Harvard Medical School, Boston, Massachusetts

1:55 - 2:10 — Yeast synaptonemal complex axial element protein Red1 binds polySUMO to activate Mec1/ATR and Tel1/ATM DNA damage checkpoint kinases
Ting-Fang Wang
Institute of Molecular Biology, Academia Sinica, Taiwan

2:10 - 2:25 — RNF4-mediated degradation of the KAP1 repressor of homologous recombination repair during DNA damage response
David K. Ann
Beckman Research Institute of City of Hope, Duarte, California

2:25 - 2:45 p.m.   Break

2:45 - 4:20 p.m.   Session IV

Moderator: Hughes de The
University of Paris, Paris, France

2:45 - 3:10 — Regulation of the hypoxic response by the von Hippel-Lindau E3 ubiquitin ligase
Lorenz Poellinger
Karolinska Institutet, Stockholm, Sweden

3:10 - 3:35 — Cbx4 sumoylates HIF-1 and its role in pathogenesis of hepatocellular carcinoma
Guo-Qiang Chen
Shanghai Jiao Tong University, Shanghai, China

3:35 - 3:50 — HECTD3 E3 ubiquitin ligase suppresses apoptosis through ubiquitinating MALT1 and Caspase-8 in breast cancer
Ceshi Chen
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

3:50 - 4:05— Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulating localization, stability and function of p53
Ronggui Hu
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

4:05 - 4:20 — Pathogenic roles of CUL4B ubiquitin ligase
Huili Hu
Shandong University School of Medicine, Jinan, China

4:20 - 4:40 p.m.   Break

4:40 – 6:00 p.m.   Session V

Moderator: James Chen
University of Texas Southwestern Medical Center, Dallas, Texas


4:40 - 5:05 — Posttranslational modifications of the ubiquitin system by bacterial pathogens
Feng Shao
National Institute of Biological Science, Beijing, China

5:05 - 5:30 — Insights into the ubiquitin and SUMO pathways from yeast
Mark Hochstrasser
Yale School of Medicine, New Haven, Connecticut

5:30 - 5:45 —The relevance of an intracellular SUMO wrestling match on the outcome of influenza viral infections in an animal model
German Rosas-Acosta
The University of Texas at El Paso, El Paso, Texas

5:45 - 6:00 — SUMOylation, an Emerging Pathway Regulating HIV-1 Post Integration Latency
Ann Marie Mc Cartin
University College Dublin, Dublin, Ireland

6:00 - 6:15 p.m.   Break

6:15 - 9:15 — Poster Session and Dinner

Sunday, May 11, 2014

7:30 a.m.   Registration 

8:30 - 10:15 a.m.   Session VII

Moderator: Michele Pagano
New York University School of Medicine, New York, New York

8:30 - 8:55 — SUMO-mediated regulation of transcription
Tony Hunter
Salk Institute for Biological Studies, La Jolla, CA

8:55 - 9:20 — Specificity in SUMO-dependent signaling pathways
Christopher D. Lima
Sloan-Kettering Institute, New York, New York

9:20 - 9:45 — Acetylation controls selective substrates for SUMO binding and conjugation
Hsiu-Ming Shih
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

9:45 - 10:00 — Structural studies of Zn(II) binding to human Ubi
Ying Huang
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

10:00 - 10:15 — SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development
Zilong Qiu
Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

10:15 – 10:45 a.m.   Break

10:45 a.m. – 12:30 p.m.  Session VIII

Moderator: Tony Hunter
Salk Institute for Biological Studies, La Jolla, California

10:45 - 11:10 — SCF ubiquitin ligase complexes regulate modular elements of molecular machines
Michele Pagano
New York University School of Medicine, New York, New York

11:10 - 11:35 — Targeting ubiquitination pathways for cancer therapy
Hui-Kuan Lin
The University of Texas M. D. Anderson Cancer Center, Houston, Texas

11:35 - 12:00 — Acetylation, instead of ubiquitination, mediates proteasomal degradation of core histones     
Xiaobo Qiu
Beijing Normal University, Beijing, China

12:00 - 12:15 — Regulation of the activity of small-g proteins via ubiquitin-dependent degradation of their gefs and gaps
Daniele Guardavaccaro
Hubrecht Institute-KNAW and University Medical Center Utrecht, The Netherlands

12:15 - 12:30 — INCA1 suppresses apoptotic HIPK2 activity and is degraded by a phospho-switch and ubiquitin ligase RNF26 upon DNA damage
Thomas G. Hofmann
German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany

12:30 – 1:30 p.m.  Lunch

1:30 – 3:30 p.m.  Session IX

Moderator: Bing Su
Shanghai Jiao Tong University School of Medicine, Shanghai, China

1:30 - 1:55 — Ubiquitin signaling in immune defense
Zhijian 'James' Chen
University of Texas Southwestern Medical Center, Dallas, Texas

1:55 - 2:20 — Ubiquitination and SUMOylation in T cells
Chen Dong
Tsinghua University School of Medicine, Beijing, China

2:20 - 2:45 — Ubiquitin signaling in the regulation of immunity and inflammation
Shao-Cong Sun
The University of Texas MD Anderson Cancer Center, Houston, Texas

2:45 - 3:00 — Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6
Chen Wang
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

3:00 - 3:15 — HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1
Xiaofeng Zheng
Peking University, Beijing, China

3:15 - 3:30 — Ubiquitination regulates stability and functions of the spinal muscular atrophy protein - survival motor neuron
Chang-Wei Liu
University of Colorado, Denver, Colorado

3:30    Adjourn for Day 

 

Monday, May 12, 2014

8:00 a.m.   Registration 

8:30 - 10:05 a.m.   Session X

Moderator: Michael Matunis
Johns Hopkins University, Baltimore, Maryland

8:30 - 8:55 — How proteotoxic stress alters the genomic and proteomic landscape of SUMO modification
Ronald Hay
University of Dundee, Dundee, United Kingdom

8:55 - 9:20 — Selective ubiquitin-dependent autophagy
Stefan Jentsch
Max Planck Institute of Biochemistry, Martinsried, Germany

9:20 - 9:35  — A SUMO acetyl-code coordinates SUMO-mediated protein interactions
Anne Gottfried
Johann Wolfgang Goethe University, Frankfurt am Main, Germany

9:35 - 9:50 — Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasis
Xiang-Dong Zhang
Wayne State University, Detroit, Michigan

9:50 - 10:05 — SUMO1 modification stabilizes CDK6 protein and drives the cell cycle in glioblastom
a
Anita Bellail
McGill University, Montreal, Canada

10:05 – 10:35 a.m.   Break

10:35 a.m. – 12:10 p.m.   Session XI

Moderator: Hsiu-Ming Shih
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

10:35 - 11:00 — The Proteasome is regulated through SUMOylation
Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, Maryland

11:00 - 11:25 — K33-linked polyubiquitination regulates protein trafficking
Ruey-Hwa Chen
National Taiwan University, Taipei, Taiwan

11:25 - 11:40 — The REGγ-proteasome pathway and its regulation of aging
Xiaotao Li
East China Normal University, Shanghai, China

11:40 - 11:55 — Ufd2 catalyzes branched ubiquitin chain assembly on substrate to promote protein degradation
Wei Li
Chinese Academy of Sciences, Beijing, China

11:55 - 12:10 — The role of ubiquitination in regulation of base excision repair
Grigory L Dianov
University of Oxford, Oxford, United Kingdom

12:10 – 1:10 p.m.   Lunch

1:10 – 2:20 p.m.    Session XII

Moderator: Christopher D. Lima
Sloan-Kettering Institute, New York, New York

1:10 - 1:35 — Fine control of TGF-beta receptor stability by ubiquitination and neddylation
Ye-Guang Chen
Tsinghua University, Beijing, China

1:35 - 1:50 — Overactivated neddylation pathway as a therapeutic target in lung cancer
Lijun Jia
Fudan University, Shanghai, China

1:50 - 2:05 — FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation
Ping Wang
East China Normal University, Shanghai, China

2:05 - 2:20 — Biomarker discovery and drug target validation with UbiScan advanced proteomic technology
Edward Li
Cell Signaling Technology, Inc. USA

2:20 - 2:50 p.m.   Break

2:50 - 4:35 p.m.   Session XIII

Moderator: Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, Maryland

2:50 - 3:15 — The role of SUMO proteases in controlling progression through mitosis
Michael Matunis
Johns Hopkins University, Baltimore, Maryland

3:15 - 3:40 — SENP3 modulates cancer cell behaviors through deSUMOylating a variety of inflammation/cancer-associated proteins
Jing Yi
Shanghai Jiao Tong University School of Medicine, Shanghai, China

3:40 - 4:05 — SUMOylation in macrophages
Jinke Cheng
Shanghai Jiao Tong University, Shanghai, China

4:05 - 4:20 — Nucleolar and nuclear functions of the SUMO-specific isopeptidase SENP3
Stefan Muller
Johann Wolfgang Goethe University, Frankfurt am Main, Germany

4:20 - 4:35 — The ROS/SUMO axis is involved in Acute Myeloid Leukemia (AML) cells response to chemotherapeutic drugs and constitutes a potential target to overcome chemoresistance in AML
Guillaume Bossis
Université Montpellier, Montpellier, France

4:35 – 4:50 p.m.   Break

4:50 – 7:50 p.m.   Session XIV Poster Session and Dinner 


Tuesday, May. 13, 2014

8:00 a.m.   Registration

8:30 - 10:05 a.m.   Session XV

Moderator: Hui-Kwan Lin
The University of Texas M. D. Anderson Cancer Center, Houston, Texas

8:30 - 8:55 — Phosphorylation-dependent regulation of ubiquitin/UBL modifications
Xinhua Feng
Zhejiang University, Hangzhou, China

8:55 - 9:20 — Role of sumoylation in zebrafish hematopoiesis
Jun Zhu
Shanghai Jiao Tong University, Shanghai, China

9:20 - 9:35 — VEGFR2 regulation by SUMOylation
Wang Min 
Yale University School of Medicine, New Haven, Connecticut

9:35 - 9:50 — Regulation of Polo-like kinase 1 interacting checkpoint helicase (PICH) activity by SUMOylation during mitosis
Yoshiaki Azuma
University of Kansas, Lawrence, Kansas

9:50 - 10:05 — SUMO-modification of CDK9 as a general mechanism for transcription repression
Jiemin Wong 
East China Normal University, Shanghai, China

10:05 – 10:30 a.m.   Break

10:30 a.m. – 12:15 p.m.    Session XVI

Moderator: Xin-Hua Feng
Zhenjiang University, Hangzhou, China

10:30 - 10:55 — To be 'ubiquitinated' or not to be, it's all about Akt phosphorylation by mTORC2
Bing Su
Shanghai Jiao Tong University School of Medicine, Shanghai, China

10:55 - 11:20 — Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth
Qunying Lei
Fudan University, Shanghai, China

11:20 - 11:35 — CRL4ACRBN E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis
Jiye Liu  
Zhejiang University, Hangzhou, China

11:35 - 11:50 — A selective USP1/UAF1 inhibitor links deubiquitination to DNA damage responses
Zhihao Zhuang
University of Delaware, Newark, Delaware

11:50 - 12:05 — Engineering ubiquitin for inhibitors and activators of human HECT E3 ligases
Wei Zhang
University of Toronto, Toronto, Ontario, Canada

12:05 - 12:15   Announcement for Poster Competition Winners
                      Closing Comments and Adjourn

12:15              Lunch

Conference Registration

Conference Website and Registration
Shanghai Jiao Tong University
School of Medicine
Yide Auditorium
227 Chongqing South Road
Shanghai 200025
China

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Conference Poster


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